Asking participants in genetic databases about their family’s medical history can help researchers uncover genetic variants tied to uncommon conditions. Because people share 50 percent of their DNA with each of their parents, siblings and children, the DNA of the participants holds clues to the conditions of these relatives.
Elizabeth Mormino knows it’s too late to save her grandfather, whose Alzheimer’s disease was diagnosed a few years ago. “It’s really hard to see a familiar face go through this, knowing that there’s really no drugs that work right now,” she says. But her work may help future patients by showing an intriguing new path to treating the disease.